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KMID : 0358119890150020003
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Journal of the Korean Public Health Association
1989 Volume.15 No. 2 p.3 ~ p.11
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EFFECTS OF MERCURY CHLORIDE ON THE LACTATE DEHYDROGENASE ISOZYME ACTIVITY IN THE MUSCLE AND KIDNEY OF CARASSIUS carassius
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黃仁澹/Hwang, In Dam
奇老錫/高大河/李宰炯/李定相/沈雲澤/Ki, No Suk/Koh, Dai Ha/Lee, Jae Hyung/Lee, Jeong Sang/Shim, Un Taek
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Abstract
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This study was investigated for the effects of mercury on the LDH isozyme patterns in the organs of goldfish, Carassius carassius, by polyacrylamide slab gel electrophoresis. The results are as follows;
1. Control groups showed tissue specific LDHisozyme bands. In the liver, LDHI, LDH3, LDH4, andELDH5 isozymes were observed and especially 5 subbands for LDHI, 3 subbands for LDH3 and 2 subbands for LDH4 and LDH5 were observed. In the muscle, LDHI with 5 subbands was observed. In the kidney, LDHI with 5 subbands and LDH2 with2 or 3,subbands were observed.
2. The accumulated concentration of mercury in the highest experimental group (300/ug) were 9.5 times higher in the kidney (139.4ug/g) than in the muscle (14.7ug/g).
In the control group, LDHI, LDH2, LDH3, LDH4 and LDH5 activities of muscle were 6.0, 17.5, 66.9, 8.4, and 1.2 percent, respectively, while those of kidney were 18.0, 21.4, 26.5, 19.9, and 14.1 percent, respectively. According to the increase of the exposure time and concentration of mercuric chloride, LDH5 isozymes were increased and LDHI was decreased in the kidney while LDH activity patterns were similar to the control -group in the muscle.
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